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M94A0183.TXT
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1994-10-08
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Document 0183
DOCN M94A0183
TI New perspectives on use of thymic factors in immune deficiency.
DT 9412
AU Cunningham-Rundles S; Harbison M; Guirguis S; Valacer D; Chretien PB;
Immunology Research Laboratory, New York Hospital, Cornell; University
Medical College, New York 10021.
SO Ann N Y Acad Sci. 1994 Aug 15;730:71-83. Unique Identifier : AIDSLINE
MED/94361420
AB Current knowledge on the role of thymic factors in the immune response
is inadequate and remains relatively primitive when compared with
present technical possibilities for assessing lymphocyte subsets or
cytokine interaction. New studies support the potential importance of
thymic factors as regulators of immune interactions. Indirect evidence
supports the concept that thymic factors may work at the level of IL-2.
The functional identity of cells responsive to thymic factors and the
relation of observed effects to cytokine network interactions need to be
established. The use of thymic factors in the future will depend on the
development of criteria to identify appropriate settings in which to use
such factors and the implementation of appropriate measures of immune
functional response.
DE CD4-CD8 Ratio Digeorge Syndrome/THERAPY Human Immunologic Deficiency
Syndromes/*THERAPY Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Thymus Extracts/PHARMACOLOGY/*THERAPEUTIC USE Thymus Gland/*IMMUNOLOGY
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).